Abstract
Novel 3-thio-1,2,4-triazoles have been obtained via a solution-phase parallel synthesis strategy, affording potent non-peptidic human somatostatin receptor subtypes 2 and 5 agonists.
MeSH terms
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Binding Sites
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Cyclic AMP / antagonists & inhibitors
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Cyclic AMP / metabolism
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Dose-Response Relationship, Drug
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Humans
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Molecular Structure
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Receptors, Somatostatin / agonists*
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Somatostatin / metabolism*
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Somatostatin / pharmacology
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Sulfides / chemical synthesis*
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Sulfides / pharmacology
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Triazoles / chemical synthesis
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Triazoles / pharmacology
Substances
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Receptors, Somatostatin
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Sulfides
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Triazoles
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Somatostatin
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somatostatin receptor 5
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somatostatin receptor 2
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Cyclic AMP